ChloroquineV1, Main, Exploration, bibRecord, 001316

Chapter 2 - Semisynthetic Artemisinin and Synthetic Peroxide Antimalarials

Identifieur interne : 001316 ( Main/Exploration ); précédent : 001315; suivant : 001317

Chapter 2 - Semisynthetic Artemisinin and Synthetic Peroxide Antimalarials

Auteurs : Leann Tilley [Australie, États-Unis] ; Susan A. Charman [Australie, États-Unis] ; Jonathan L. Vennerstrom [Australie, États-Unis]

Source :

RSC Drug Discovery [ 2041-3203 ]

RBID : ISTEX:96A579B3F3FB4974AA584D392FB46233F6345048

Abstract

Since the discovery of the endoperoxide sesquiterpene lactone artemisinin, numerous second-generation semisynthetic artemisinins and synthetic peroxides have been prepared and tested for their antimalarial properties. Using a case-study approach, we describe the discovery of the investigational semisynthetic artemisinins artelinic acid (8) and artemisone (9), and the structurally diverse synthetic peroxides arteflene (10), fenozan B07 (11), arterolane (12), PA1103/SAR116242 (13), and RKA182 (14).

Url:

https://api.istex.fr/ark:/67375/P0J-QGD1PT8D-F/fulltext.pdf

DOI: 10.1039/9781849733496-00033

Affiliations:

Australie, États-Unis

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Le document en format XML

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Chapter 2 - Semisynthetic Artemisinin and Synthetic Peroxide Antimalarials

Chapter 2 - Semisynthetic Artemisinin and Synthetic Peroxide Antimalarials

Source :

Abstract

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